Except "you probably won't get this, but try anyway" is pretty much the point, both of Upstream Color, and Carruth's previous film Primer. In fact that's what I loved about both. (Though I found Upstream Color much more comprehensible on first viewing than Primer.) The entire point of both Carruth films is for the audience members to emotionally inhabit the characters predicaments, which are intensely bewildering and complex. That's not an aim most film makers try to tackle, and for that I applaud him.
And I'm afraid you contradict yourself with this review. If you found the film bewildering enough to not become emotionally involved, then how can it's ideas not be tricky or complex?